Greetings. Here's a tip:
I've been working on some tunes that I'm using eigenD's Recorders to record loops. I noticed that some parts, particularly bass or bass-like patches, when the loops start, would produce some audio crackles (overloading the system a bit).
After some experimentation, I found that if I turn the volume for the parts down a bit in eigenD's console mixer, the glitches stop. I lower the individual instrument's level, not the Master/ Then, I just turn the audio interface up a bit to compensate and all is well.
A larger buffer may also stop the glitches, but it's not worth it to me. I set the audio buffer to 384 -- that's as far out as I want to go so I don't get latency that affects my playing.
Hope this helps someone.