Being a clarinet/EWI player I instinctively pick up the Pico with my left hand uppermost. I just noticed in the tutorials though that the loverly Nick is holding it with the right hand uppermost. This also makes a bit more sense of the secondary mode key being upper right.
So I'm a bit torn. Is it worth me training myself to swap hands? If I stick with left hand at the top am I going to regret it later? Can't think why right now, but my experience of this instrument isn't very deep yet.